Psidium guajava L. (Myrtaceae) has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Psidium guajava L. was used for investigation of antiulcer activity by using pylorus ligation as antisecretary model and Indomethacin & ethanol induced ulceration models as cytoprotective model. Animals pretreated with ethanolic extract of Psidium guajava L.at the dose 200 mg/kg and 400 mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggested that the extract at 200 mg/kg and 400 mg/kg showed significant protection (P<0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that Psidium guajava L.bark extract shows significant antiulcer activity.
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